This report evaluates the effect of iliac conduits on TEVAR outcomes.

Methods: The 2005-2010 American College of Surgeons Surgical Quality Improvement Program database was queried to identify vascular patients undergoing elective TEVAR. Patients without

conduit (Group A) were compared to patients who underwent TEVAR with conduit (Group B).

Results: We identified 1037 patients (90%) in Group A (69 +/- 12.7 years, 42% female) and 117 patients (10%) in Group B (70 +/- 12.6 years, 68% female). Women received conduits more often than men (Male:5.8%, Female:15.7%; p < 0.001). There was no significant difference in the rate of non-surgical (A:19%,B:25%,p = 0.121), pulmonary (A:11%,B:16%, p = 0.115), renal (A:3.1%, B:1.7%, p = 0.4) and cardiovascular complications (A:8%, B:12%, p = 0.143) between groups. However, any complication (A:24%, B:33%. p = 0.025), SYN-117 surgical complications (A:10%, B:16%, p = 0.035) and mortality (A:4.5%, B:12%. p = 0.001) were significantly higher in Group B. In multivariate analysis, use of conduit was associated with a 3.8 times higher risk of death compared with no conduit after controlling for confounders. Length of in-hospital stay was similar for both groups (A:6.6 +/- 8.8, B:7.6 +/- 8 days, p = 0.247). The use of conduits

had a declining rate over time from 17.9% in 2006 down to 6.5% in 2010.

Conclusions: Selleckchem ATM inhibitor Female patients more frequently require iliac conduits during learn more TEVAR compared to men. Conduits were associated with a higher rate of surgical complications and mortality. The incidence of conduit use has decreased threefold in the last five years. Safer access

for TEVAR by use of a conduit should not be abandoned based on these results, but there should be a heightened awareness for the higher rate of mortality in these patients. (C) 2013 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.”
“The primary aim of this study was to gain more insight into maturation arrest of spermatogenesis (MA) and its relationship with mutations in genes essential for meiosis. The study also investigated the possibility that mutations in human meiosis genes cause a milder phenotype and that, in such cases, meiosis could potentially be completed with the production of mature germ cells having an abnormal chromosomal constitution causing miscarriage. Among 40 patients with MA, five changes were observed that also predicted alterations at the amino acid level. However, since these changes were also present in men with normozoospermia in equal frequencies, it was assumed that these changes are single nucleotide polymorphisms. Among 46 patients with recurrent miscarriages, two additional changes were detected predicting an alteration at the amino acid level. One change was detected in controls.