The proximal and learn more distal segments of the diaphysis were then aligned with use of an intramedullary rod as an anatomic axis template and with use of the contralateral extremity as a length and rotation template. The patients were assessed clinically and radiographically at a mean of thirty-one months (range, six to fifty-two months) after the osteotomy.

Results: Complete angular correction was achieved in each case; the amount of correction ranged from 20 to 200 in the coronal plane, from

01 to 320 in the sagittal plane, and from 00 to 250 in the axial plane (rotation). Correction of length ranged from 0 to 5 cm, and limb length was restored to within 2 cm in all patients. All osteotomy sites were healed clinically by six months. While no deep infections occurred, superficial wound dehiscence occurred in two patients along the approach for the longitudinal portion of the osteotomy, emphasizing the importance of careful soft tissue handling and patient Temsirolimus selection.

Conclusions: The clamshell osteotomy provides a useful way to correct many

forms of diaphyseal malunion by realigning the anatomic axis of the long bone with use of a reamed intramedullary rod as a template. This technique provides an alternative that could decrease preoperative planning time and complexity as well as decrease the need for intraoperative osteotomy precision in a correctly chosen subset of patients with diaphyseal deformities.”
“Three tumor cell lines of lung (A549), colon (HT29) and breast (MDA-MB-231) were used to evaluate the antiproliferative effect of ethanol and dichloromethane extracts and seven fractions obtained by flash column chromatography from the most bioactive extract of the sponge Leucetta aff. floridana. Ethanol extract showed antiproliferative activity on

three cell lines, whereas dichloromethane extract exhibited low activity. Four ethanol fractions showed antiproliferative activity, which was higher on A549 (IC50 for all four fractions: < 1.0 mu g/mL), followed by HT29 ( IC50: 2.5 mu g/mL; 2.2 mu pg/mL; 13.2 mu g/mL and 15.8 Fludarabine inhibitor mu g/mL) and finally, MDA-MB-231 (IC50: 2.8 rho g/mL, 83 mu g/mL; 133 mu g/mL and 20.5 mu g/mL). GC. MS analysis of the highest activity fraction permitted to identify sixteen fatty acids among saturated, branched-saturated, monounsaturated and polyunsaturated of which hexadecanoic and hexadecenoic acids were the most abundant fatty acids.”
“Epidermolysis bullosa pruriginosa (EB-Pr) is an unusual variant of dystrophic EB. Potential genetic disease modifiers and metabolic factors have been investigated, but thus far no specific insight into this phenotype has emerged. We report an in-depth description of three patients diagnosed as having EB-Pr in whom this particular phenotype developed after scabies infestation and dramatically improved after full treatment.