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“Purpose It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy.

Methods Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical,

radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients’ medical records.

Results There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients Selleck ABT 263 were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance.

Conclusions Size of adrenal lesion, suspicious radiological

findings and history of malignancy were factors associated with malignancy.”
“In the present study an accurate and check details selleck screening library precise HPLC-UV method in rat plasma has been developed and validated for simultaneous determination of S001-281, a new synthetic azulene antiosteoporotic compound, and its sulfoxide metabolite. Separation was achieved using a reversed phase column with a mobile phase comprising acetonitrile and ammonium

acetate buffer pH 6 (gradient elution) using a UV detector set at a wavelength of 308 run. The method, applicable to 200 mu L plasma, involved double extraction of the samples with diethyl ether. The absolute recovery of both the analytes was > 90 %. The method was sensitive with a limit of quantitation of 25 ng/mL in rat plasma. Precision and accuracy were within the acceptable limits as indicated by bias varying from -0.11 to 16.93 % and precision values ranged from 2.0 to 12.7 %. Moreover, S001-281 was stable in rat plasma tip to 30 days of storage at -60 degrees C and after being subjected to three freeze/thaw cycles. The method was applied to generate the pharmacokinetics of S001-281 in rats after single dose oral administration.”
“OBJECTIVES: Guidelines recommend the avoidance of direct return of pericardial blood based on evidence from coronary surgery. A continuous auto-transfusion system (CATS) can be a good alternative to cardiotomy suction by reinfusing aspirated pericardial blood without the necessity of intermittent collection.