Plasma elimination was faster for MCT:FO than for MCT:LCT (half-life: 24.5 +/- 3.5 min compared with 32.9 +/- 3.0 min; P < 0.025). This was associated with a greater increase in the plasma nonesterified fatty acid concentration. The content of n-3 PUFAs, specifically
eicosapentaenoic acid (20:5n-3), increased in leukocyte and platelet phospholipids within 60 min and >= 24 h after MCT:FO injection.
Conclusion: Bolus intravenous injection of a novel MCT:FO emulsion allows rapid enrichment of cells with n-3 PUFAs. Am J Clin Nutr 2010; 91: 875-82.”
“Background RepSox cell line and aims: The prevention of cardiovascular risk, as occurs in lipoprotein disorders, is required since childhood. Aim of the study was to evaluate, in a group of children affected by primary dyslipidemia, the efficacy, tolerability and safety of a short-term treatment with a dietary supplement containing red yeast rice extract and policosanols.
Methods and Results: 40 children affected by heterozygous Familial Hypercholesterolemia (FH) (n = 24) and Familial Combined Hyperlipidemia (FCH) (n = 16), aged 8-16 years, were enrolled in a double-blind, randomized, placebo-controlled, cross-over trial. After a 4-week run-in period with only dietary advice, children received a dietary supplement containing 200 mg red yeast rice extract, corresponding to 3 mg of monacolins, and 10 mg policosanols once-daily and placebo for 8 weeks, separated by a 4-week washout
period. Lipid profile was assessed after each treatment period.
The selleck inhibitor dietary supplement, compared with selleck chemical the placebo, significantly reduced total cholesterol by 18.5% (p < 0.001), LDL-C levels by 25.1% (p < 0.001), and apolipoprotein
B by 25.3% (p < 0.001) when patients were considered as a whole group. Similar results were obtained when FH and FCH were considered separately and no significant difference between groups was detected. No significant differences were observed in HDL-C and apolipoprotein A-I levels. No adverse effects were detected when liver and muscular enzymes (AST, ALT, and CK) were determined.
Conclusions: The treatment with a dietary supplement containing red yeast rice extract and policosanols has been for the first time successfully employed in hypercholesterolemic children. Results indicate this strategy as an effective, safe and well tolerated in a short-term trial. (C) 2009 Published by Elsevier B.V.”
“A perpendicularly exchange-coupled composite structure, which consists of a [Co/Ni](N) multilayer and a ferrimagnetic TbCo layer, displays specific features when it is utilized as a reference layer in spin valves. By slightly increasing the TbCo thickness, the coercivity of the coupled structure greatly increases, thereby giving an effective way to widen the difference in switching fields for the free and reference layers, and making it possible to manipulate magnetizations parallel or antiparallel for a wide range of fields.