The Manchester scientists found a new drug, and the new drug can inhibit the tumor growth. The new drug, together with the radiation therapy, could be applied for effective treatment of tumor in the clinical.

In the process of tumor cell metabolism, the lactic acid was produced. The Lactic acid cause toxicity to tumor cells, so the lactic acid must be transferred by the molecular transporters (MCT) out of tumor cells. Astrazeneca pharmaceutical drug-AZD3965 inhibited a MCT1 in lung cancer cells. Researchers of the Manchester investigated the therapeutic effect of the drug combined with radiotherapy. The further study confirmed that the new drug, together with the radiation therapy, could be applied for effective treatment of tumor in the clinical.

Professor Ian Stratford said AZD3965 can inhibit MCT1, specifically targeting tumor by tumor metabolism. This drug was used as a single drug test in clinical trials. And he has shown that the drug combined with radiotherapy could be the new treatment of cancer patients.

Reference:

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport [J]. Mol Cancer Ther, 2014; 13(12): 1-12.