Monensin enhances the cytotoxicity of ricin entrapped in various charged

liposomes depending on the surface charge. Maximum potentiation of cytotoxicity of ricin was observed when it was delivered through negatively charged liposomes having 5 mol% PEG-2000 on the surface. Studies on the kinetics click here of inhibition of protein synthesis by ricin revealed that the lag period of inhibition of protein synthesis is significantly lengthened following its delivery through various charged liposomes. Monensin significantly reduced the lag period of action of ricin. It was also observed that the efficacies of monensin on the enhancement of cytotoxicity of ricin entrapped in various charged PEG-liposomes were highly related to their amount of cell association. The current study has demonstrated that by suitable adjustment of charge, density, and chain length of PEG on the surface of liposomes it would be possible to direct liposomal ricin to human tumor cells for their selective elimination in combination with monensin.”
“Contrasted with partially hydrolyzed polyacrylamide (HPAM), the self-assembly behavior and microstructure

of hydrophobically associating polyacrylamide (HAPAM) in aqueous solution have been studied by means of fluorescence spectrum, transmission electron microscopy (TEM), atomic force microscope (AFM), and apparent viscosity test in this article. The fluorescent probe analysis indicates that the HAPAM molecules will form associating aggregates in pure water. selleck chemicals llc The results show that HAPAM can easily self-assemble to form an aggregate by hydrophobic driving force in dilute aqueous solution. The association of hydrophobic groups of the HAPAM causes the formation of supermolecule, Tariquidar manufacturer so there are associating aggregates formed at very low concentration and then

leads to the formation of network at a higher concentration. TEM and AFM measurements show that a distinct network structure has been formed in 1000 mg L(-1) of HAPAM solution, indicating the strong association of hydrophobic groups. These results are consistent with the viscosity measurement and reveal that the excellent viscosification of HAPAM is due to the association of hydrophobic groups in the aqueous solution. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 2397-2405, 2012″
“Postictal aphasia may be a feature of Todd’s paralysis or the presentation of aphasic nonconvulsive status epilepticus (NCSE). We describe a 74-year-old woman with three episodes of aphasic status epilepticus after prolonged generalized tonic-clonic seizures. In the first episode, the NCSE was not definitively diagnosed, but an increase in the epileptic medication led to resolution of the epileptic activity within 2 weeks. During the second episode, NCSE was terminated within 7 days under intensified antiepileptic treatment.