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“Lipomas are benign mesenchymal tumors composed of mature lipocytes grown in different parts of the body. The giant lipomas are very rare in children, however, highly active antiretroviral treatment (HAART) can increase their frequency.
We present a case of a HIV-infected child who developed the rapidly growing lipoma
in the thigh after receiving long-term HAART.
The purpose of this report is to highlight the existence of unspecific clinical presentation of lipodystrophy syndrome as the side effect of long HAART in children.”
“BackgroundTo date, extensive research has been undertaken NSC 649890 HCl on a potential link of breastfeeding (BF) to wheezing illnesses. Nevertheless, an association remains to be established, partly due to age-dependent discrepancies and different definitions of exposures/outcomes across studies. We thus investigated the relation of diverse infantile feeding patterns with wheeze/asthma prevalence in two cohorts of children of different ages (preschool and preadolescent).
MethodsWheeze Fer-1 inhibitor ever/in the last 12months (current) and doctor-diagnosed asthma were retrospectively reported by parents of the participants of two cross-sectional studies: the Genesis study (1871 children aged 1-5) and the Healthy Growth study (1884 children aged 9-13). Information on feeding practices (exclusive breastfeeding vs. mixed vs. formula feeding)
and their duration (2 vs. 4 vs. 6months) was recorded. Perinatal and anthorpometric data were also collected.
ResultsIn pre-schoolers, regimes that did not entail exclusive BF were positively correlated to current/ever wheeze, both before and after adjustment for confounders. No differences between the associations of regimes with 2, 4 or 6months of exclusive BF with current/ever wheeze were shown. selleck chemical Furthermore, there was no consistent correlation of feeding practices with physician-diagnosed asthma. In pre-adolescents, no association of infantile feeding patterns with the wheeze/asthma outcomes
was observed.
ConclusionsExclusive BF is associated with reduced prevalence of current/ever wheeze in pre-schoolers; however, this appears to wane in older children. The association of a period of exclusive BF as low as 2months with pre-school wheeze prevalence, appeared to be comparable with that of 6months of exclusivity.”
“Antibody-based therapeutics are of great value for the treatment of human diseases. In addition to functional activity, affinity or physico-chemical properties, antibody specificity is considered to be one of the most crucial attributes for safety and efficacy. Consequently, appropriate studies are required before entering clinical trials.
High content protein arrays are widely applied to assess antibody specificity, but this commercial solution can only be applied to final therapeutic antibody candidates because such arrays are expensive and their throughput is limited.