“
“Adrenocortical

tumors are rare in childhood and adolescence. Virilization, alone or in combination with signs of overproduction of other adrenal hormones, is the most common clinical presentation. Here we report an unusual case of an African-American female adolescent presenting with idiopathic acquired generalized anhidrosis, dysregulation of see more body temperature, absence of adult body odor and dry skin in the face of a virilizing para-adrenocortical adenoma. Virilization signs regressed soon after removal of the tumor, but normalization of the 3 alpha-androstenediol glucuronide (3 alpha-AG) took longer compared to other measurable androgens; accompanied by anhidrosis. The association of remitting anhidrosis with normalized levels of 3 alpha-AG suggests it might be a possible mechanism for anhidrosis. High 3 alpha-AG levels might implicate the increased peripheral conversion of weak pro-androgens with different biochemical structure. We recommend obtaining 3 alpha-AG beside other androgens in virilized patients with atypical dermatological symptoms in the face of hyperandrogenism.”
“Background and Aims: Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular MK-2206 cell line risk factors including hypertension

and obesity. Various food ingredients such as polyphenols have been shown to improve FMD. We investigated whether consuming resveratrol, a polyphenol found in red wine, can enhance FMD acutely and whether there is a dose-response relationship for this effect.

Methods and Results: 19 overweight/obese (BMI 25-35 kg m(-2)) men or post-menopausal women with untreated borderline hypertension (systolic BP: 130-160 mmHg or diastolic

BP: 85-100 mmHg) consumed three doses of resveratrol (resVida (TM) 30, 90 and 270 mg) and a placebo Capmatinib nmr at weekly intervals in a double-blind, randomized crossover comparison. One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log10 plasma resveratrol concentration (P < 0.01).

Conclusion: Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine. (C) 2010 Elsevier B.V. All rights reserved.