The waist-to-hip ratios were converted to age- and sex-adjusted z scores based on normal ranges in healthy Thai children.\n\nResults: Forty-five lipodystrophic children with 36 episodes of lipohypertrophy and 22 episodes of lipoatrophy were enrolled. By weeks 48 and 96 after substitution, 40% and 47% of lipohypertrophy resolved, whereas 59% and 73% of lipoatrophy resolved,
respectively. The rate of resolution of lipoatrophy was higher than that of lipohypertrophy at 48 weeks after substitution and thereafter. Ninety-six weeks after changing to zidovudine therapy, 8 children still had LD (1 with both lipoatrophy and lipohypertrophy, 7 with lipohypertrophy). No clinically significant hematologic adverse event was observed.\n\nConclusions: Substitution click here of stavudine
with zidovudine resulted in decreased severity or resolution of LD among HIV-infected children and adolescents.”
“Aim: To examine the effectiveness of continuous haemofiltration Compound C ic50 as a treatment for severe heat stroke in dogs.\n\nMethods: Dogs were randomly allocated to a control or continuous haemofiltration group (both n=8). Heat stroke was induced by placing anaesthetised dogs in a high temperature cabin simulator. Upon confirmation of heat stroke (rectal temperature > 42 degrees C, mean arterial pressure (MAP) decrease > 25 mmHg), dogs were removed from the chamber and continuous haemofiltration was initiated and continued for 3 h for dogs in the continuous haemofiltration group. Dogs in the control group were observed at room temperature.\n\nResults: Rectal temperature, haemodynamics, pH, blood gases and electrolyte concentrations rapidly returned to baseline in the continuous haemofiltration group, but not the control group. After
3 h, rectal temperature was 36.68 +/- 0.51 degrees C in the continuous haemofiltration group and 39.83 +/- https://www.selleckchem.com/products/azd5363.html 1.10 degrees C in the control group (P<0.05). Continuous haemofiltration prevented endotoxin and all serum enzyme concentrations from increasing and caused malondialdehyde concentrations to decrease. After 3 h, endotoxin concentrations were 0.14 +/- 0.02 EU ml(-1) in the continuous haemofiltration group and 0.23 +/- 0.05 EU ml(-1) in the control group (P=0.003), while malondialdehyde concentrations were 4.86 +/- 0.61 mmol l(-1) in the continuous haemofiltration group and 8.63 +/- 0.66 mmol l(-1) in the control group (P<0.001). Five dogs died in the control group within 3 h, whereas no dogs died in the continuous haemofiltration group.\n\nConclusions: Continuous haemofiltration rapidly reduced body temperature, normalised haemodynamics and electrolytes, improved serum enzyme concentrations and increased survival in dogs with heat stroke. Continuous haemofiltration may be an effective treatment for heat stroke. (c) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Purpose of review\n\nTo highlight recent literature that informs our understanding of severe asthma.