For polymeric constructs, increasing dose intensity and cumulative dose strongly affects the therapeutic index and reveals a major therapeutic advantage for the FR-targeted formulation. All DDS were able to abrogate doxorubicin-induced cardiotoxicity. This study constitutes the first side-by-side comparison of two receptor-targeted ligand-bearing systems, polymer therapeutics versus nanoparticulate systems, evaluated in
the same mouse tumor model BMS-777607 solubility dmso at several dosing regimens. (C) 2015 Elsevier B.V. All rights reserved.”
“The purpose of this work was to test whether fractional anisotropy (FA) can contribute to the diagnosis and grading of prostate cancer. Turbo spin echo T2-weighted (T2W) and single shot echo planar imaging diffusion tensor imaging (EPI DTI) data were collected from 13 subjects with biopsy proven prostate cancer prior to surgical removal of the gland. Rapid acquisition with relaxation enhancement Lazertinib in vivo (RARE) T2W and spin-echo DTI data were acquired ex-vivo from the fixed prostatectomy specimens. Digitized whole mount histology sections, examined and annotated by a pathologist, were registered to the in-vivo and ex-vivo DTI data, and the average values of apparent diffusion
coefficient (ADC) and FA were calculated from ROIs encompassing normal and cancerous peripheral zone (PZ). In addition, Monte Carlo simulations were carried out to assess the dependence of the apparent FA on the ADC values for
different signal to noise ratios (SNRs). ADC values were significantly lower in tumors than in normal PZ both in-vivo and ex-vivo, while the difference in FA values between tumors and normal PZ was significant only in-vivo. Paired t-test showed significant difference between in-vivo and ex-vivo FA values in tumors, but not in the normal PZ The simulations showed that lower SNR results in an increasing overestimation of the FA values with decreasing ADC. These results suggest that the in-vivo increase in FA values in tumors is due to low SNR, rather than the presence of cancer. The results of this study suggest that FA does not BI 6727 order contribute significantly to the diagnostic capabilities of DTI in prostate cancer. (C) 2015 Elsevier Inc. All rights reserved.”
“The value and predictive power of nonclinical studies for potential effects of investigational medicinal products in humans is often debated. The subject of general predictivity of animal toxicity studies has been addressed on several occasions, with one of the most recent efforts being conducted by an ILSI Task Group [Olson H, et al. Concordance of the toxicity of pharmaceuticals in humans and animals. Regul Toxicol Pharmacol 2000; 32: 56-67].