umbelliflora
were investigated for their antioxidant activity using DPPH, reducing potential and beta-carotene-linoleate system. Total phenolics and flavonoids contents were also determined. E. brasiliensis and E. beaurepaireana showed the highest antioxidant capacities in all methods used. These species exhibited too the highest phenolic contents. A significant relationship between antioxidant capacity PF 00299804 and total phenolic content was found, indicating that phenolic compounds are the major contributors to the antioxidant properties of these plants.”
“Objective: To evaluate first and second-trimester maternal serum markers in pregnancies complicated with inherited thrombophilias. Methods: A case-control study was conducted in 50 pregnancies complicated with hereditary thrombophilia and 100 control pregnancies. Results: Each woman with inherited thrombophilia received low molecular weight heparin (LMWH) throughout her pregnancy. Gravidity, parity, number of first-trimester and second-trimester abortions, and rate of adverse pregnancy outcomes (APO) were significantly higher in the thrombophilia group compared
to the control group (P < 0.001 for all). Among the thrombophilia group median values of pregnancy associated placental protein-A (PAPP-A) (0.6 vs. 0.9; P < 0.001) and free beta-human chorionic gonadotropin (beta-hCG) (0.9 vs. 1.1; P = 0.001) in the first trimester; median values of alpha-fetoprotein (AFP) (0.7 vs. 1.1; drug discovery P = 0.027), unconjugated estriol 3 (uE3) (0.9 vs. 1.1; P < 0.001), and hCG selleck kinase inhibitor (0.7 vs. 1.2; P < 0.001) in the second trimester were significantly lower with respect to control pregnancies. Multivariate analysis
revealed that low uE3 and hCG levels were independently associated with APO. Conclusion: Pregnant women with hereditary thrombophilias, all of whom were treated with LMWH, had decreased levels of all first and second trimester serum markers. In addition, levels of hCG and uE3 in the second trimester could independently predict placenta-related disorders and adverse outcomes in these patients.”
“The production of biopharmaceuticals by transgenic plants is a promising choice to achieve the multi-kilogram amount of products needed to treat many human diseases. However, this scientific field is still lacking of approved specific guidelines regarding points to consider for manufacturing and application of these products. In such sense, the implementation of new manufacturing processes and quality systems using the quality risks management is recognized as something of prime importance in the current pharmaceutical industry. In this work, we summarize the application of the FMEA method to design the manufacturing process of a plantibody, employed in the hepatitis B vaccine production to ensure the vaccine high quality.”
“Objective: The etiology of placental calcification (PC) is lack of research.