All of the patients with HBsAg
loss received entecavir as 0.5 mg. Conclusion: Our results are consistent with the previous reports. Therefore, it may be suggested that treatment with entecavir could be associated to HBsAg loss in a period of time, in both HBeAg positive and HBeAg negative HBV patients. Key Word(s): 1. viral hepatitis B; 2. entecavir; 3. HBSAG loss; Presenting Author: ALI BAHARI Additional Authors: MOHAMMAD HASHEMI, GHOLAM REZA BAHARI, ZOHREH BARI, TAHEREH FAKHARIAN, ALI MOKHTARI FAR, ABBAS ESMAEIL ZADEH, AZITA GANJI, HAMID REZA SIMA, ZAHRA MESHKAT, SINA GERAYLI, SEYED MOUSAALREZA HOSSEINI, HOOMAN MOZAFFARI, MITRA AHADI, HASAN check details VOSUGHINIA, ALIREZA BAKHSHIPOUR Corresponding
Author: ALI BAHARI Affiliations: Mashhad University of Medical Sciences; Mazandaran University of Medical Sciences Objective: Different studies have shown that single nucleotide polymorphisms (SNPs) in the gene coding for interleukin 28 (IL28B), including rs12979860 and rs8099917, influence hepatitis C viral response to treatment and accordingly, CC genotype of rs12979860 and TT genotype of rs8099917 parallel with EPZ-6438 ic50 sustained virological response. The present study assessed the distribution of these two SNP genotypes and their relation with some clinico-pathologic characteristics in a population of Iranian patients. Methods: DNA of 148 patients with chronic HCV infection were analyzed to selleckchem determine the allele frequency
of rs12979860 and rs8099917 SNPs, using Tetra-ARMS polymerase chain reaction. We also evaluated the relation between different SNP genotypes and liver function tests, viral load, pathology of liver biopsy, HCV genotype and the patient’s gender. Results: The genotype distribution of rs12979860 was: 72.3% CT, 14.2% TT and 13.5% CC. Also, the frequencies of rs8099917 genotypes were: 58.1%, 38.5% and 3.4% for TT, TG and GG, respectively. Totally, 12.1% were CC/TT and 2.7% were TT/GG (rs12979860/rs8099917, respectively). No relation was found between different genotypes of these two SNPs and the level of alanine amino-transferase (ALT), liver fibrosis, viral load, HCV genotype and the patients’ gender. Conclusion: According to our results, rs12979860 and rs8099917 genotypes are independent of the patient’s gender, severity of liver fibrosis, viral load, viral genotype and the level of ALT. Besides, although CC had the lowest frequency among rs12979860 genotypes, further studies are needed to assess the predictive power of these genotypes in this country. Key Word(s): 1. Hepatitis C; 2. IL28B ; 3. single nucleotide polymorphism; Presenting Author: YONGSEOK KIM Additional Authors: YUMI LEE, OHJUNG KWON Corresponding Author: YONGSEOK KIM Affiliations: Konyang Univ. Hospital Objective: Gallstone disease is one of the most common and costly of all digestive diseases.