Most study participants reported treating with recommended foods in quantities exceeding minimum recommendations, possibly attempting to resolve unpleasant symptoms of hypoglycaemia quickly. Failure of many to ingest follow-up food is concerning and warrants investigation. Increased patient education and standardisation of guidelines for treatment of hypoglycaemia are indicated. Copyright © 2012 John Wiley &

Sons. ”
“Alström syndrome, Selleckchem INCB024360 a rare autosomal recessive ciliopathy (OMIM 203800), is classically diagnosed on the basis of childhood onset cone rod retinal dystrophy, sensorineural hearing loss and obesity with severe insulin resistance. In addition, in infancy acute reversible cardiomyopathy occurs in 30% of cases, and type 2 diabetes develops in most cases in young adulthood. We describe the audit of 11 cases of Alström syndrome diagnosed as adults, eight in the context of diabetes clinics who were referred to the National Specialised Commissioning Team (NSCT) adult Alström clinic at Torbay Hospital. All have severe insulin resistance, dyslipidaemia and a variable degree of cardiac, renal and musculoskeletal involvement – features not associated with PARP inhibitor a unifying diagnosis until referred to their local diabetic clinics in eight of them. Obesity and young onset type 2 diabetes are increasing and it is important to be aware that some

cases will have associated rare recessive conditions such as Alström syndrome, Wolfram syndrome, lipodystrophies, Bardet Biedl syndrome (LMBBS), Prader Willi syndrome or occult cystic fibrosis. Early recognition of Alström families will facilitate prompt recognition Amine dehydrogenase and treatment of comorbidities and genetic counselling. Copyright © 2011 John Wiley & Sons. ”
“Diabetes remains one of the most prevalent long-term conditions that we all face. The latest estimates from the International Diabetes Federation suggest that 382 million people had diabetes in 2013 and by 2035 this will rise to 592 million.1 In the UK it is estimated that almost 3 million people already have the condition. In addition to the numerous challenges that outpatients with the condition face, diabetes is associated with an almost doubling of the risk of hospitalisation

when compared to someone without diabetes.2 Data from the 2012 National Diabetes Inpatient Audit (NaDIA) showed that the mean prevalence of diabetes in hospitalised patients was 15.2% (range 5.5–31.1%).3 NaDIA also confirmed previous work that showed that people with diabetes spend longer in hospital than those without diabetes,4 but also showed that unlike those without diabetes, emergency admissions were far more common. Data from 2009/10 suggested that together these, and other, factors cost the NHS an estimated £2.51 billion per year.5 The saying goes that ‘prevention is better than cure’, and with these data in mind it would seem to make sense to try and prevent hospital admission if at all possible to reduce the burden on the health economy.