The mixture was inhi

The mixture was neutralized with concentrated hydrochloric acid, so the solid PF-06463922 chemical structure separated was collected and crystallized from suitable solvent to obtain the chalcone derivatives with 85–90% yield. 178–180 °C, IR (KBr): 1511, 1649, 2840, 2917, 1H NMR (CDCl3) δ ppm; 3.82 (s, 3H, –OCH3), 6.63–6.65 (d, 1H, –CO-CH), 7.38–7.41 (d, 1H, CH–Ar) 7.02–8.32 (m, 13H, Ar–H); 13C NMR (40 MHz, DMSO-d6): δ 54.43, 113.83, 114.50, 116.32, 118.17, 118.63, 121.54, 121.90, 128.37, 128.69, 130.63, 131.78, 133.89, 143.48, 157.02, 159.38, 165.36, 189.14. Mass (m/z): 333. Anal. (%) for C22H18O3, Calcd. C, 79.95; H, 5.45; Found: C, 79.93;

H, 5.80. A mixture of 1-(4-methoxyphenyl)-3-(3-phenoxyphenyl) prop-2-en-1-one (0.01 mol), thiourea (0.01 mol) and sodium hydroxide (0.01 mol) in methyl alcohol (25 ml)

was refluxed for 8 h. when the completion of reaction, the resultant mixture was cool to room temperature. The compound was separated, filtered, washed with water, dried and crystallized MLN0128 with methyl alcohol get titled compound with 82% yield. mp. 160–162 °C, IR (KBr): 1175, 1625, 2846, 2928, 1H NMR (CDCl3) δ ppm; 8.83 (s, 1H, NH), 3.81 (s, 3H, –OCH3), 7.08–8.11 (m, 14H, Ar–H); 13C NMR (40 MHz, DMSO-d6): δ 55.13, 113.83, 14.50, 109.76, 116.63, 118.48, 118.87, 121.54, 121.89, 128.37, 128.69, 129.63,, 136.09, 157.80,165.64, 160.58, 164. 63, 181.14. Mass (m/z): 386. Anal. (%) for C23H18N2O2S, Calcd. C, 71.46; H 4.67; N 7.23; Found: C, 71.53; H, 4.81; N 7.41. In conical flask take 0.01 mol substituted benzothiazole in 25 ml benzene and mixed up to 30 min in ice-bath until temp below 0–5 °C then add drop by drop 0.01 mol chloroacetyl chloride in conical flask at intervals of 2 h. After complete addition reflux it for 2 h in water bath then cool it and evaporate it and collect compound. inhibitors recrystallization from alcohol afforded yield 88% of yellow needles, IR (KBr): 752, 1728, 3345, 1H NMR (CDCl3) δ ppm 9.20 (s, 1H, NH), 7.53–8.26 (m, 4H, Ar–H); 13C NMR (40 MHz, DMSO-d6): Megestrol Acetate δ 43.67, 118.31, 121.89, 124.53, 125.32,130.67, 153.41, 165.42, 174.47. Mass (m/z): 226. Anal. (%) for C23H18N2O2S, Calcd. C, 47.67; H 3.10; N 12.34; Found: C, 47.53; H, 3.16;

N 12.41. In R.B.F take 0.01 mol 4-(4-methoxyphenyl)-6-(3-phenoxyphenyl) pyrimidine-2-thiol in 25 ml acetone then add 0.01 mol substituted N-(1,3-benzothiazole-2yl)-2-chloro acetamide and add 2–3 drop TEA as a catalyst and reflux it for 3 h then cool it and fall out in ice precipitate come out filter it and recrystallization from alcohol. Yield 70%, mp. 110–113 °C, IR (KBr): 3175, 2917, 2840, 1690, 1602, 1530, 745, 695.

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