Mean background levels of ROS and bSO did not differ between caro

Mean background levels of ROS and bSO did not differ between carotenoid-treated and control males. bSO, which represents the superoxide level in un-manipulated blood, was negatively correlated with colour development in all males, regardless of carotenoid treatment. Thus, carotenoid intake does not reduce circulating levels of ROS or bSO, suggesting that AZD3965 molecular weight carotenoids are inefficient antioxidants in vivo and, therefore, are unlikely to provide a direct link between oxidative stress

and colouration.”
“Background: Due to the lack of country-specific norms in Saudi Arabia, age- and gender-specific lipid reference intervals are needed to be established

for Saudi children.\n\nMethods: Blood samples were collected from 1168 children aged 6-16 years: 500 boys (43%) and 668 girls (57%), and were analyzed for cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Reference intervals were established by calculating the mean and the 2.5th and 97.5th percentiles.\n\nResults: There were significant differences between boys at each Tanner stage with respect to cholesterol (P < 0.001); and HDL (P < 0.0001) but not LDL (P < 0.06) among girls. There were significant differences between boys and girls during puberty with respect to cholesterol (P < 0.0001), HDL (P < 0.0001), and LDL (P < 0.001). There was a significant positive

BIIB057 clinical trial correlation between total cholesterol levels, LDL and HDL levels at all Tanner stages in both genders. In girls, the only significant inverse correlation was at stage I (r = -0.243, P = 0.001); there was no significant correlation at other stages.\n\nConclusions: Unlike children in other developing countries, Saudi children do not have lower serum cholesterol than theirWestern counterparts. These findings reflect changing dietary habits and increasing affluence in Saudi Arabia. These reference intervals may be used to aid in the early assessment of cardiovascular risk in Saudi pediatric populations.”
“Fifteen new ent-kaurane diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K alpha radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line.

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