High expression of MAGE-A9 correlates with unfavorable survival in HCC

Research from Xuefeng Gu and Maoying Fu showed that High expression of MAGE-A9 correlates with unfavorable survival in HCC. They concluded for the first time that MAGE-A9 can be recognized as a prognostic factor in HCC and that targeting MAGE-A9 may provide apromising therapeutic strategy for HCC treatment. Further studies that included more clinical samples of HCC are necessary to confirm our findings and to elucidate the possible mechanisms of MAGE-A9 characteristics in HCC.

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In this study, they first investigated MAGE-A9mRNA expression in cell lines by RT-PCR. The results showed elevated MAGE-A9 expression in four HCC cell lines compared to non-cancerous cell lines. Subsequently, the expression of MAGE-A9 mRNA in fresh

HCC tissues and matched non-cancerous tissues was evaluated by qPCR.

 For survival analysis, Cox proportional hazards regression models,in which the effect of covariates is to multiply the hazard function by a function of the explanatory covariates, have achieved widespread application in the analysis of time-to-event data, with censoring and covariates. Their research team also constructed an anti-MAGE-A1 immunotoxin and verified its anti-tumor effectiveness. Considering the oncogenic role of MAGE-A9 in cancer, the application of treatment targeting MAGE-A9 is anticipated, and a fully human anti-MAGE-A9 antibody is currently being generated by their research group.

 Reference

Xuefeng Gu, Maoying Fu and Zhijun Ge,etc. High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma, Scientific Reports4, Article number:6625 doi:10.1038/srep06625

 

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