1). 1 104 of the patients (21%) were assigned the code A10 – Chest pain according to the Index, corresponding to a rate of 5.4 (95% CI 5.3-5.6) chest pain cases reported to the EMCCs per 1000 inhabitants per year. Further analyses are based on the 1 104 patients with code A10 – Chest pain. Figure 1 Flow chart of AMIS forms received for registration, with both excluded and included incidents. The patients’ age ranged from 4 to 97 years (median (25th-75th percentile): 65 (53-79)), 56% males with a median age of 61 (25th-75th percentile: 52-75), and 44% females Inhibitors,research,lifescience,medical with

median age 70 (25th-75th percentile: 56-82). The males were significantly younger than the females (p < 0.0001), and males dominated the age group 30-69 years with 63%, while the females constituted the majority (54%) in the age group > 70 years (Figure ​(Figure2).2). There were only minor differences in the distribution of patients

around-the-clock. Figure 2 Study patients with acute chest pain, by age and gender. The primary care doctor on-call Inhibitors,research,lifescience,medical was alerted by radio alarm in 351 (36%) of the cases, of which the doctor responded with an emergency call out in about a third. The doctors’ Inhibitors,research,lifescience,medical responses and choices of action are shown in Table ​Table1.1. In 417 (38%) of the medical emergencies with chest pain as the main symptom, the caller to the EMCC was a next-of-kin, in 173 (16%) the patient, and a layperson made the call in 61 (6%). A physician called directly to the EMCC for assistance in 108 (11%) of the cases, while the call came from other health personnel in 314 (29%) of the cases. Table 1 Alerting of doctors with their response, prehospital response time, air ambulance Inhibitors,research,lifescience,medical involvement and to where the patients were brought by NACA-score Median prehospital response Inhibitors,research,lifescience,medical time

was 13 Compound C solubility dmso minutes (95% CI 9-20), and over 90% of the patients were reached by an ambulance in less than 30 minutes. Figure ​Figure33 shows the number of patients reached per minute (Figure ​(Figure3a)3a) and cumulative by percentage (Figure ​(Figure3b3b). Figure 3 Prehospital response time, defined as the time period from the caller calls the emergency number 113 until the nearest available ambulance resource reaches the patient. a. Number of patients reached per minute b. Number of patients reached, until cumulative … NACA-score could be classified in 971 (88%) of the patients (table ​(table1),1), with 87 (9%) given NACA-score 0 or 1, indicating no illness or an illness not requiring medical attention. Overall, the female patients were given lower NACA-scores than the male patients, indicating less severe symptoms (p < 0.001), and in the group NACA 1, females constituted 59% of the patients (p < 0.01). Males dominated among the patients given NACA 4-6 (67% of the 163 patients, p < 0.001). Among the 10 patients who were dead, nine were male (p < 0.05). Figure ​Figure44 shows severity of illness (NACA-scores) in study patients, by gender.