These 5 patients showed all remained HCC viable tissue, 1 patient showed 4week MRI positive finding and the other 4 patients showed
12week MRI positive. On the contrary, among patient who showed 4week CT scan positive without 4week CEUS positive, no one finally diagnosed as having viable HCC positive. Especially, among 8 patients of 4week CEUS positive, 4 patients (50%) did not presented 4week MRI positive and they all finally confirmed to have remained HCC tissue just by 12week MRI test. Conclusions: In assessment see more of therapeutic response of TACE, early 4week CEUS showed excellent result in diagnosis and prediction of remained viable HCC. However, this result was derived from just small samples as preliminary study and has to be followed by more advanced well designed large population study. Keywords: Hepatocellular carcinoma, transarterial chemoembolization, contrast-enhanced ultrasonography Disclosures: The following people
have nothing to disclose: Moon Young Kim, Soon Koo Baik, Mee-Yon Cho, Youn Zoo Cho, Won Ki Hong, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Seung Yong Shin, Jung Min Kim, Erlotinib research buy Sang Ok Kwon, Dong Joon Kim, Ki Tae Suk, Gab Jin Cheon, Dae Hee Choi Hadrien Dyvorne1, Guido H. Jajamovich1,M. Isabel Fiel1, Scott L. Friedman1, Douglas T. Dieterich1, Claudia Donnerhack1, Richard Ehman2, Bachir Taouli1 1Icahn School of Medicine at Mount Sinai, New York, NY; 2Mayo Clinic, Rochester, MN Introduction To assess the diagnostic value of multiparametric MRI including diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE MRI), MR elastography (MRE), compared to transient elastography (TE) for detection of liver fibrosis. Methods This study was approved by the local IRB and all subjects gave informed consent upon enrollment.48 subjects underwent MRI and TE exams.48 subjects were enrolled (9 volunteers and 39 with chronic liver disease). DWI was performed using 16 b values and diffusion decay was fitted to the intravoxel incoherent motion model to yield D (true diffusion),
PF (perfusion fraction), D* (pseudo diffusion) and ADC (apparent diffusion). DCE MRI was acguired after gadolinium contrast injection and a dual input single compartment model to yield arterial, portal and hepatic flow (Fa, Fp, Ft), arterial 上海皓元医药股份有限公司 fraction (ART), distribution volume (DV), mean transit time (MTT) and time to peak (TTP). Liver stiffness was measured with MRE (LSMRE) and TE (LS-TE). Comparisons between noninvasive modal-ities and fibrosis METAVIR stages findings on histopathology were performed using Spearman correlation. ROC analysis was performed to assess the performance of each technigue for the detection of moderate (F2-F4) or advanced (F3-F4) fibrosis. Results Correlations with fibrosis stage were significant for D (r =-0.58, p<0.001), ADC (r = -0.50, p=0.001), MTT (r = 0.44, p=0.011), TTP (r = 0.47, p=0.005), LS-MRE (r = 0.77, p<0.001) and LS-TE (r = 0.66, p<0.001).